The Might Warriors of Zimbabwe overcame their northern border neighbours Zambia 6-3 on aggregate in the preliminary round to set up the potentially explosive first round tie with the South Africans.
The meeting between the Limpopo rivals will be played over the weekend of February 22-24 in Harare, with the return leg scheduled for March 7-9 in Tshwane.
Zimbabwe, coached by former national team striker Moses Chunga, have assembled a team that is hoping to make inroads in Africa.
Banyana and the Mighty Warriors have met on a number of occasions in the last couple of years, with matches dominated by August Makalakalane’s side.
Banyana may, however, have to negotiate for the services of star striker Portia Modise, who is now playing her club football in Denmark, as qualifiers fall outside the Fifa calendar.