Head coach Jill Ellis has retained 20 members of the squad that competed in friendlies against Japan last month and also recalled co-captain Carli Lloyd who missed the 1-0 victory over Japan due to a knee injury.
The two sides have never met before and both are using the friendly, which will take place at Soldiers Field in Chicago, to prepare for the 2016 Rio Olympic Games.
This particular fixture could prove to be a tough one for Banyana as the USA are unbeaten in 12 matches played this year, winning 11 and drawing one.
The game also holds special significance for stars from the respective teams with Amanda Dlamini of Banyana Banyana and Hope Solo of the USA both poised to make their 100th appearance should they feature.
Solo could become the first goalkeeper in US and world history to achieve that milestone of 100 games should she play against South Africa.
Ashlyn Harris (Orlando Pride), Alyssa Naeher (Chicago Red Stars), Hope Solo (Seattle Reign FC)
Whitney Engen (Boston Breakers), Jaelene Hinkle (Western New York Flash), Julie Johnston (Chicago Red Stars), Meghan Klingenberg (Portland Thorns FC), Ali Krieger (Washington Spirit), Gina Lewandowski (FC Bayern Munich), Kelley O’Hara (Sky Blue FC), Becky Sauerbrunn (FC Kansas City), Emily Sonnett (Portland Thorns FC)
Morgan Brian (Houston Dash) Tobin Heath (Portland Thorns FC), Lindsey Horan (Portland Thorns FC), Carli Lloyd (Houston Dash), Allie Long (Portland Thorns FC), Megan Rapinoe (Seattle Reign FC), Samantha Mewis (Western New York Flash), Heather O’Reilly (FC Kansas City)
Crystal Dunn (Washington Spirit), Alex Morgan (Orlando Pride), Christen Press (Chicago Red Stars), Mallory Pugh (Real Colorado)