Sundowns are carrying a 5-0 lead to Egypt after recording a historic CAF Champions League victory over their opponents in Tshwane last week.
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The game between the Egyptian side and The Brazilians was initially set for Suez Stadium but has been switched to Borg El Arab Stadium about 350km away from Cairo.
Gassama is set to be assisted by Senegalese match officials Djibril Camara and El Hadjie Malick Samba as the first and second assistant referees respectively.
Maguette Ndaye of Senegal was in charge of the first leg at Lucas Moripe Stadium, assisted by Elvis Guy Noupue Nguegoue of Cameroon and Seydou Tiam of Barkina Faso.
