Messi, 31, sealed all three points for Barca in the Catalan derby on Saturday with another masterful display, scoring a brace at the Camp Nou.
While his incredible free-kick was initially dotted down as a Victor Sanchez own goal, the Argentina international was later credited with the strike upon review as he moved a step closer to a record sixth Golden Shoe title.
Meanwhile, Mbappe scored for a seventh consecutive Ligue 1 outing, taking his overall tally to 27 goals in 24 league game this season.
With Italy record-breaker Fabio Qualiarella failing to score for the first time in over a month, the prolific duo are seemingly uncontested by the rest of Europe's most lethal attackers.
1. Messi (31 goals, 62pts) - FC Barcelona
2. Mbappe (27 goals, 54pts) - Paris Saint Germain
3. Quagliarella (21 goals, 42pts) - Sampdoria
4. Piatek (19 goals, 38pts) - AC Milan
5. Ronaldo (19 goals, 38pts) - Juventus
In Spain, England, Italy, Germany and France goals are worth two.
In countries between six and 22 in UEFA's rankings 1.5.
The rest of the leagues 1 point.