Missing the suspended Lionel Messi, Barcelona ran out comfortable winners at Nuevo Los Cármenes thanks to goals from Luis Suarez, Paco Alcacer and Matthieu Saunierho who put the ball into his own net.
Neymar rounded off the scoring in stoppage time and reached his century of goals for the Catalan club in just 177 appearances.
Enrique was full of praise for the Brazil international after the game.
The Spanish mentor said: "He has numbers [which show he is] a beast of a footballer.
"He's one of the most unbalancing players in the world [for opposition defences] and his signing by this club was a great decision.
"I hope he scores another 900 goals, so we can keep seeing him at Barcelona for many more years."