Messi announced his retirement following Argentina's Copa America Centenario final defeat to Chile earlier this month.
The five-time Ballon d'Or winner missed his attempt in the penalty shootout after the match ended in a 0-0 stalemate, seeing his national team go for a third successive major tournament without a winners medal, after the 2014 World Cup and 2015 Copa America.
The Barca manager, however, believes the 29-year-old's decision would aid the Catalan giants as their star forward will enjoy more breaks rather than doing intenrational duty.
"Speaking as Barcelona's head coach, it wouldn't be bad for us," Luis Enrique said. "It means fewer games and trips away for Messi.
"I'm not saying it's a perfect situation but he could have more time to rest."
However, Enrique admits that he too is uncertain over whether Messi will uphold his decision or not, and adds that he would like to continue watching the diminutive attacker continue playing for the Albiceleste.
"He said that after a difficult time, after losing a final. So he still needs to confirm whether or not he part of the international team," he added.
"As a football fan, I would like to keep watching him play for Argentina. But as Barcleona's head coach.... Let's see what happens."