Manzini top scored for TTM last season and has now moved on to another Limpopo club Venda Football Academy – who also play in the Motsepe Foundation Championship.
The 34-year-old has signed a one-year deal.
He is expected to lead the VFA attack considering his experience.
Venda finished fifth last season after buying the franchise of Cape Umoya United.
Manzini has previously played for Jomo Cosmos, Sivutsa Stars, Witbank Spurs, Platinum Stars, Chippa United, and AmaZulu.
Sources at the club also conform that former Highlands Park right-back Ricardo Versuur has also joined.