The game will start at 15h00 at Dr Petrus Molemela Stadium in Bloemfontein on Saturday.
Senong has retained most of the team that won 2-0 in Maseru.
The winner will qualify for the CAF African Youth Championships in Zambia next year, with the best three teams on the continent earning a ticket to the FIFA U-20 World Cup in South Korea in 2017.
“We are all excited about the progress and the idea of qualifying for the CAF championships and it is every player and coach’s dream of playing in major continental and global tournaments,” said Senong.
“The boys are looking sharp and we know Lesotho will not be a pushover but we need to be well prepared and I am confident we will deliver. Lesotho intend to spoil the party but if we play well, consolidate our position, keep the ball, work hard as a team and not get too excited, we will make it.
“We need to protect our two goals we scored in the first leg and if we score an early goal, it will help us control the game without much pressure.”