The match will kick off at 16h00 local time (17h00 SA time) at the Abuja National Stadium.
Bantwana, who left South Africa on Tuesday, will host the return leg on March 26 at Makhulong Stadium in Tembisa, Johannesburg.
The upcoming tie will be South Africa’s first official match in the World Cup qualifiers after their opposition in the previous round, Zambia, withdrew from the competition.
On the other hand, Nigeria booked their spot in the third round after beating Namibia 9-0 on aggregate in January.
Bantwana’s stand-in coach Maude Khumalo is aware of the threat that the West Africans pose, but insists that they will not be bullied out of an opportunity to qualify for Jordan 2016.
“We will not be a walk over for the Nigerians, we intend on fighting for this qualifier. South Africa missed out on the last World Cup and would want to change that. The girls are very hungry, very determined and motivated by the prospects of their future. A win is very important so that we return home with less pressure and hopefully finish off the job in Johannesburg,” said Khumalo.