Khanyisa bagged a hat-trick in South Africa's 6-0 thrashing of Congolese giants TP Mazembe in the Durban International U-19 football tournament on Sunday.
The 17-year-old SuperSport United forward also scored a brace in their opening Group B clash, which they won 3-2 against Scottish side Glasgow Rangers.
Mkhalele, who is currently assisting David Notoane in the absence of Thabo Senong, is confident that Mayo will emulate his father, who also represented Bafana in his heyday, but urges him to remain humble to reach his full potential.
"This boy has a bright future, and the only thing he will have to ensure is that he continues to work hard because he's got huge potential," Mkhalele tells KickOff.com.
"He knows how to combine with his teammates, so what is important right now is how he takes care of himself outside of football because it is important that he takes care of his body also.
"Having said that, I have no doubt that he will follow in his father's footsteps on the field, so I'm hopeful he will not have any problem in achieving that."
'Midnight Express' also believes Khanyisa, who represented Molefi Ntseki's Amajimbos side during the 2015 FIFA under-17 World Cup in Chile, is ready to turn out for the Matsatsantsa senior team under the correct guidance of coach Stuart Baxter.
"I think he's got chance now to play for his club in the PSL," he adds. "But he will need to be introduced slowly, and not be rushed because he's still a young boy, who has shown us that he has magnificent talent."
Notoane's side are currently top of their group with six points from two games, and will finish complete the round-robin phase on Tuesday against Brazilian side Fluminense at Sugar Ray Xulu Stadium.