Leopards have found the going tough since gaining promotion to the topflight, as they are currently propping up the Absa Premiership table with five points from six games.
Lidoda Duvha suffered a third straight loss on the weekend, a 4-0 mauling by SuperSport United at Lucas Moripe Stadium.
However, Masutha has faith his men will turn their campaign around.
"I am not pressing panic buttons. I have played football. We've lost games," said Masutha, who revealed a number of his players were struggling with abdominal pains against SuperSport in Tshwane.
"Sometimes we played eight games without a win but ended up starting to win again and being in a comfortable position.
"I am not panicking. I believe in these boys. I believe we will regroup, rectify our mistakes and come back strong."
The Limpopo-based outfit next host derby rivals Baroka at Thohoyandou Stadium on October 3.