This, after Sundowns dropped two more vital points following the 0-0 draw against Bloemfontein Celtic last night, which made it five without victory in the league.
And with Mosimane admitting his side have blown a big advantage in the league, he has also warned SuperSport United and Bidvest Wits of the struggles of balancing domestic and continental title challenges.
When asked who he thought the Premiership title favourites are, Mosimane said: "I told you, [Kaizer] Chiefs and Cape Town City."
"Because it's not easy, especially when you try to rotate [players], It's very difficult to do [get right].
"We [Sundowns] have done it, last year, and we won three trophies, so you have to do it [keep the whole squad fresh], let's just see if [Wits and SuperSport] can really do it. It's not an easy thing to do, it's a very difficult thing to do," he added.
Cape Town City are currently top of the league table with 42 points after 22 games, while Bidvest Wits and Kaizer Chiefs sit second and third with 41 and 39 points respectively. SuperSport United remain fourth with 37 points.