Meyiwa, the first-choice Bafana Bafana and Pirates goalkeeper, was laid to rest this past weekend after being gunned down in Vosloorus on October 26.
Mhlongo is expected to don the gloves ahead of Philani Zikalala when Bucs play their first game since Meyiwa's passing against SuperSport United in the Telkom Knockout semi-finals on Saturday night.
"I think it's important not to undermine Brighton," says Palacios.
"He has played for the senior team before and also played a number of games in the First Division. He has learnt a lot from Senzo, Moeneeb Josephs and the goalkeeper coach at Pirates.
"Senzo also had to wait for his chance after both Francis Chansa and Josephs. Brighton also come from our development, he has been waiting for his chance. We also have to give him a chance.
"I also have confidence in Philani Zikalala and I have no doubt that he can do the job," adds 'Njenje'.
The former Bafana Bafana boss has also called on Vladimir Vermezovic's squad to stay united in this trying time.
"The players must be united and deserve to dedicate all their next games to Senzo," Palacios says.
Meanwhile, Sea Robbers fan Msobho Sithole concedes Meyiwa's successor faces a daunting task.
"Senzo was not only a keeper at Pirates but our own son. We are gonna miss him," says Sithole.
"It will be difficult to replace but we confident that who ever takes over will do the job for the team. We are ready to support him and the whole team."
Sithole urged the supporters to show patience with whoever stands in goal.
"We will continue to honour and respect the role played by Senzo at Pirates. I believe all players have their own weaknesses and strong points. Senzo had a shaky start but continued to improve. We must also give support to the next keeper even if he does mistakes."