Kane, who appears to be set for a return to action on Saturday following a short spell on the sidelines, has been the London side's most valuable player since the Argentine took charge three years ago.
This season has seen Kane in fine form again, his 19 league goals helping his club to a second consecutive season of challenging for the Premier League title.
Now, as the player prepares to return to the first XI following three matches on the sidelines due to an ankle injury, his manager has hailed his importance, despite the Lillywhites' dominant performances in his absence.
"I'm not doubting Harry Kane," Pochettino told reporters. "If he plays from the beginning or not, I think there's no doubt that Harry is one of our best players.
"In Barcelona, Messi was injured for a month but Barcelona were still winning, and then when Messi's available again, you don't say 'hmm, I don't know.
"Different names, I can't tell you. But there's no doubt Harry's one of the best players that we have," he added.
"We'll see whether he will start the game or be on the bench," the Argentinean continued, in reference to the likelihood of Kane being in the starting lineup in Spurs' upcoming match against Watford on Saturday.
"But it's good news that he's ready. He feels good about his recovery. It's very good news for him and for us. He's an important player for us, and for him to be available for us is great.
"We are happy, he's ready, maybe normally after one month out you need to feel the competition. But he's a special player, he tries to push himself a lot," the 45-year-old added.