Santos were 2-0 up at half time, after a goal by Erwin Isaacs, who shot into the top right of goal from a Musa Otieno cross, and another from Mogogi Gabonamong.
AmaZulu were given some hope when Romano Scott handled the ball in the area in the 56th minute, and Siyabonga Mkhwanazi converted with a well-taken penalty.
But Isaacs got his brace in the 69th minute, scoring from a Ryan Chapman cross, making the score 3-1.
AmaZulu got one back in the dying seconds of the game, Litha Ngxabi scoring from the penalty area, but the game ended 3-2.
