A number of Premiership-based foreigners will get a taste of the action on Saturday when Togo host Zambia and Botswana are home to Madagascar.
Bafana Bafana has their key game against Nigeria’s Super Eagles on Sunday.
Other matches that will attract attention on the second day are the Ivory Coast v Mozambique and the Guinea v Zambia encounters.
The full list of fixtures is:SaturdayBlantyre: Malawi v DjiboutiGabarone: Botswana v MadagascarYaounde: Cameroon v Cape Verde IslandsLibreville: Gabon v LesothoKigali: Rwanda v MauritaniaAccra: Togo v ZambiaDar es Salaam: Tanzania v MauritiusWindhoek: Namibia v KenyaKampala: Uganda v NigerCasablanca: Morocco v EthiopiaDakar: Senegal v AlgeriaOmdurman: Sudan v Chad
SundayLuanda: Angola v BeninMalabo: Equatorial Guinea v Sierra LeoneBujumbura: Burundi v SeychellesAbuja: Nigeria v South AfricaMonrovia: Liberia v GambiaAbidjan: Ivory Coast v MozambiqueConakry: Guinea v ZimbabweKumasi: Ghana v LibyaRades: Tunisia v Burkina FasoBamako: Mali v CongoCairo: Egypt v Congo DR