Zuma missed a vital match against Hamburg SV last Saturday as his German club Arminia Bielefeld sought to stave off relegation danger.
He resumed training in midweek according to officials but will likely not start the match at home to Karlsruhe.
Rowen Fernandez, having overcome the broken finger injury that kept him sidelined during the African Nations Cup finals in Ghana, keeps his place in goal for a third successive match. The game pits Fernandez against another former Wits University and Kaizer Chiefs player, in the form of Bradley Carnell.
Bielefeld are second bottom in the standings with 22 points from 26 games. A win, however, could lift them out of the danger zone. Karlsruhe lie midway in the standings in ninth place.