Higuain, 31, won 75 caps for his country, scoring 31 goals but was often made the scapegoat for his nations shortcoming on the international stage.
Having joined Chelsea on loan from Juventus via a stint at AC Milan in January, the prolific striker has called time on his national team career.
"I've made the decision because I want to enjoy my family, I want to spend time with my daughter and at the same time I feel that I gave my country everything I could," Higuain said, as per BBC.
"I'm fully focused on my commitment to Chelsea. The Premier League is amazing and I really want to enjoy it. It's very competitive indeed."
The former Real Madrid attacker, who ranks as the sixth highest scorer in La Albiceleste history and only three strikes behind legend Diego Maradona also sent out a message to his detractors.
"People remember the goals I missed and not the ones I scored. I'm sure everyone celebrated the goal against Belgium [the winner in the 2014 World Cup quarter-final]," he told Fox Sports.
"When you criticise someone maliciously it hurts everyone. I saw how much my family suffered, but I gave everything for the national team.
"It's one thing to say that the national team did not achieve our objectives, but when people talk about failure it's very hard."