With Cameroon confirming the 2021 showpiece has been moved back to the traditional January - February dates due to weather conditions the Reds will be hit hard.
Salah (Egypt), Mane (Senegal) and Keita (Guinea) could all be lost for six games around the busiest period of the season in England.
"I couldn't respect the Africa Cup of Nations more than I do because I like the competition and watched it a lot in the past. It's a very interesting tournament," Klopp told BBC Football.
"But, it's an obvious problem that you play a tournament in the middle of the season, although it makes more sense for Africa to play it in our winter when the weather is better for them - I get that.
"But we have absolutely no power - so if we did say 'We don't let him go', the player is suspended."
Amidst the unease, the Mirror claims Klopp is now looking towards accelerating their intentions to land RB Leipzig and Germany striker Timo Werner to consolidate any sort of issues.
Citing German publication BILD, Werner is believed to hold a £51 million release clause in his current contract that the European champions are keen to explore.